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In this condition, the severely damaged kidneys work under 10% of their normal functioning. With symptoms like nausea, vomiting, fatigue, decreased urination, loss of appetite, edema, numbness in the limbs, bone pain and confusion, this can also be a cause of muscle fasciculation or muscle twitching. Medullary Cystic Kidney Disease – The rare condition called medullary cystic kidney disease is characterized by Twitch APK formation of small, fluid-filled sacs, known as cysts, in the middle of the kidneys.

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